A PTPN22 promoter polymorphism −1123G>C is associated with RA pathogenesis in Chinese

@article{Huang2010APP,
  title={A PTPN22 promoter polymorphism −1123G>C is associated with RA pathogenesis in Chinese},
  author={Jian-Jun Huang and Yu-Rong Qiu and Hai-xia Li and De-hua Sun and Jia Ning Yang and Chun-li Yang},
  journal={Rheumatology International},
  year={2010},
  volume={32},
  pages={767-771}
}
The minor allele of the non-synonymous single nucleotide polymorphism (SNP) +1858C>T within the PTPN22 gene has now been unequivocally confirmed as conferring susceptibility to RA in population from Europe and America, but not in population from Asia. The aim of this study was to jointly address and integrate these separate findings to further elucidate the association between the PTPN22 gene and RA in Chinese Hans of Guangdong province. Four hundred and ninety-four cases with RA and 496… CONTINUE READING

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