A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells.

@article{Nagashima2011APM,
  title={A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells.},
  author={Shigeo Nagashima and Masaharu Takahashi and Jirintai and Toshinori Endo Soichi Ogishima Hiroshi Tanaka and Kentaro Yamada and Tsutomu Nishizawa and Hiroaki Okamoto},
  journal={The Journal of general virology},
  year={2011},
  volume={92 Pt 2},
  pages={269-78}
}
We have previously demonstrated that the release of hepatitis E virus (HEV) from infected cells depended on ORF3 protein, which harbours one or two PSAP motifs. To elucidate the PSAP motif(s) in the ORF3 protein during virion egress, five PSAP mutants derived from an infectious genotype 3 cDNA clone of pJE03-1760F/wt that can grow efficiently in PLC/PRF/5 cells were analysed. Four mutants, including mutLSAP, mutPSAL, mutLSAL (the substituted amino acids in the authentic PSAP motif are… CONTINUE READING

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