A PPARgamma mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus.

@article{Berger2000APM,
  title={A PPARgamma mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus.},
  author={Joel P. Berger and Hansa V Patel and J A Woods and Nancy S Hayes and Stephen A. Parent and Joseph A Clemas and Mark D. Leibowitz and Alex Elbrecht and Richard A Rachubinski and John P. Capone and David Moller},
  journal={Molecular and cellular endocrinology},
  year={2000},
  volume={162 1-2},
  pages={57-67}
}
The peroxisomal proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily that act as ligand-activated transcription factors. PPARgamma plays a critical role in regulating adipocyte differentiation and lipid metabolism. Recently, thiazolidinedione (TZD) and select non-TZD antidiabetic agents have been identified as PPARgamma agonists. To further characterize this receptor subclass, a mutant hPPARgamma lacking five carboxyl-terminal amino acids was produced… CONTINUE READING
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