A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.

@article{Chowdhury2008APC,
  title={A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.},
  author={Dipanjan Chowdhury and Xingzhi Xu and Xueyan Zhong and Fariyal Ahmed and Jianing Zhong and Ji Liao and Derek Michael Dykxhoorn and David M. Weinstock and Gerd. P. Pfeifer and Judy Lieberman},
  journal={Molecular cell},
  year={2008},
  volume={31 1},
  pages={33-46}
}
The histone H2A variant H2AX is rapidly phosphorylated in response to DNA double-stranded breaks to produce gamma-H2AX. gamma-H2AX stabilizes cell-cycle checkpoint proteins and DNA repair factors at the break site. We previously found that the protein phosphatase PP2A is required to resolve gamma-H2AX foci and complete DNA repair after exogenous DNA damage. Here we describe a three-protein PP4 phosphatase complex in mammalian cells, containing PP4C, PP4R2, and PP4R3beta, that specifically… CONTINUE READING
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