A POSSIBLE ROLE OF SEROTONIN IN HYPOTHALAMIC SELF-STIMULATION IN DOGS.

@article{Stark1964APR,
  title={A POSSIBLE ROLE OF SEROTONIN IN HYPOTHALAMIC SELF-STIMULATION IN DOGS.},
  author={Paul Stark and Eugene S. Boyd and Ray W. Fuller},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1964},
  volume={146},
  pages={
          147-53
        }
}
Electrodes were chronically implanted in dogs in the area of the medial mammillary nucleus of the posterior hypothalamus. These animals were trained to press a lever for electrical stimuli at various current intensities. Drugs were administered which altered the brain levels of serotonin and catecholamines. The effects of these drugs and a serotonin antagonist on the thresholds for self-stimulation response rates were measured. The administration of α-methyl dopa, which lowers the brain levels… CONTINUE READING