A POSSIBLE ROLE FOR LIPOXYGENASE PRODUCTS AS REGULATORS OF AIRWAY SMOOTH MUSCLE REACTIVITY

@article{Adcock1980APR,
  title={A POSSIBLE ROLE FOR LIPOXYGENASE PRODUCTS AS REGULATORS OF AIRWAY SMOOTH MUSCLE REACTIVITY},
  author={John J. Adcock and L G Garland},
  journal={British Journal of Pharmacology},
  year={1980},
  volume={69}
}
The size of guinea‐pig isolated tracheal contractions induced by histamine was substantially augmented by pretreatment with the cyclo‐oxygenase inhibitor, indomethacin. However, compounds which inhibit both the cyclo‐oxygenase and lipoxygenase pathways of arachidonic acid metabolism not only did not augment histamine‐induced contractions of the guinea‐pig trachea, but also completely reversed the increased reactivity to histamine produced by indomethacin. The SRS‐A (slow reacting substance of… Expand
MODIFICATION OF HUMAN AIRWAY SMOOTH MUSCLE REACTIVITY BY DRUGS THAT INTERFERE WITH ARACHIDONIC ACID METABOLISM
TLDR
Mixed cyclo‐oxygenase/lipoxygen enzyme inhibitors of arachidonic acid metabolism did not modify histamine‐induced contractions of smooth muscle from either small or large airways but completely reversed the augmentation of histamine responses produced by indomethacin on the smaller airways. Expand
THE EFFECT OF MIXED INHIBITORS OF CYCLO‐OXYGENASE AND LIPOXYGENASE ON THE INDOMETHACIN‐INDUCED HYPER‐REACTIVITY IN THE ISOLATED TRACHEA OF THE PIG
  • H. Mitchell
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1982
TLDR
The results provide further support for a lipoxygenase‐dependent component of indomethacin‐induced hyper‐reactivity in the pig trachea. Expand
THE EFFECT OF INHIBITORS OF ARACHIDONIC ACID METABOLISM ON DRUG‐INDUCED CONTRACTIONS IN ISOLATED TRACHEAL SMOOTH MUSCLE OF THE PIG
  • H. Mitchell
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1982
TLDR
The possibility that histamine H1‐agonist‐induced contractions are regulated by contractile products of the arachidonic acid lipoxygenase pathway is discussed. Expand
Effects of leukotriene D4 and antagonists of arachidonic acid metabolism and calcium entry on guinea pig tracheal muscle responsiveness.
TLDR
The data suggest that indomethacin- and LTD4-potentiation of guinea pig airway muscle responsiveness to certain bronchoconstrictors may be mediated, at least in part, by enhanced extracellular Ca++ entry. Expand
Pharmacological studies into cyclo‐oxygenase, lipoxygenase and phospholipase in smooth muscle contraction in the isolated trachea
  • H. Mitchell
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1984
TLDR
The results with BW755c and phenidone suggest that muscle reactivity (to histamine) may be partly determined by the balance between the release of inhibitory and contractile arachidonate metabolites. Expand
Prostaglandin synthesis inhibitors: effect on angiotensin II‐ and oxytocin‐induced contractions in rat uterine smooth muscle
  • M. M. Hall
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1983
TLDR
It can be implied that some product of the arachidonate lipoxygenase pathway augments peptide‐induced contractions of the rat uterus. Expand
EFFECT OF ETYA AND BW 755c ON ARACHIDONATE‐INDUCED CONTRACTIONS IN THE GUINEA‐PIG ISOLATED TRACHEA
  • H. Mitchell
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1982
TLDR
The results show that arachidonate lipoxygenase products may be responsible for the contractile responses seen in the presence of indomethacin. Expand
The effects of arachidonic acid and non‐steroidal anti‐inflammatory drugs on intrapulmonary airways of the guinea‐pig
TLDR
It is suggested that both cyclo‐oxygenase and lipoxygenases products are associated with the maintenance of airway tone and the primary arachidonate metabolite present in intrapulmonary airways following histamine‐induced constriction is probably a relaxant of the E series. Expand
Interaction between chloroquine and indomethacin in airways smooth muscle in vivo.
TLDR
Observations indicate that histamine-induced bronchospasm in vivo is modulated by the arachidonate system and that chloroquine-type phospholipase A2 inhibitors may ameliorate such bronchingospasm and explain the observed clinical benefits of chloroquines in chronic asthmatics. Expand
Prostaglandin D2 (PGD2) potentiates cholinergic responsiveness in guinea-pig trachea.
TLDR
A role of PGD2 in the genesis of hyperreactivity of tracheal smooth muscles, particularly in a model of pulmonary anaphylaxis, is suggested. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 10 REFERENCES
Contractile responses of the guinea-pig trachea in vitro: modification by prostaglandin synthesis-inhibiting drugs.
TLDR
The results suggest that basal tension of the guinea-pig trachea may be due to an intramural production of PGF2alpha and that during the development of active tension, prostaglandins E2 and F2alpha are released which modulate the intensity of the contraction. Expand
The mechanism of enhancement by fatty acid hydroperoxides of anaphylactic mediator release.
TLDR
It is concluded that 13-HPLA enhances mediator release not by altering the balance of arachidonic acid metabolites, e.g. by inhibiting synthesis of prostacyclin, but by a direct effect on lung mast cells. Expand
Enhancement of anaphylactic mediator release from guinea-pig perfused lungs by fatty acid hydroperoxides.
TLDR
The fatty acid hydroperoxides may enhance mediator release either indirectly by augmenting thromboxane production or by a direct effect on sensitized cells. Expand
Selective inhibitor of slow reacting substance of anaphylaxis.
TLDR
The activity of the racemic mixture of the sodium salt of this compound is described as an antagonist of unpurified guinea-pig and human SRS-A and partially purified rat S RS-A. Expand
Bronchial Hyperreactivity to Prostaglandin F2α and Histamine in Patients with Asthma
TLDR
It is suggested that endogenous, locally formed PGF2α may play an important part in the pathogenesis of bronchial asthma. Expand
Leukotriene C: a slow-reacting substance from murine mastocytoma cells.
TLDR
On the basis of isotope incorporation experiments, spectroscopy, and chemical degradations, the SRS was identified as a cysteine-containing derivative of 5-hydroxy-7,9,11,14-icosatetraenoic acid, and the name "leukotriene" has been introduced to designate these compounds. Expand
Comparison of respiratory and cardiovascular effects of isoproterenol, propranolol, and practolol in asthmatic and normal subjects.
TLDR
The results suggest that practolol does not significantly affect the beta-2 bronchial receptors, is safe to use in asthmatic subjects, and is consistent with an abnormality of these receptors in Bronchial asthma. Expand
Comparison of respir
  • 1976