A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis.

Abstract

The construction of transgenic FVB/N mice targeting the PMLRARA fusion gene under the control of a human MRP8 promoter recapitulated the phenotype of acute promyelocytic leukemia but had the unexpected result of multiple squamous papillomas of the skin (Brown et al., PROC: Natl. Acad. Sci. USA, 94:2551-2556, 1997). In addition, transgenic MRP8-PMLRARA mice… (More)

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@article{Hansen2003APT, title={A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis.}, author={L. A. MD Salmon Hansen and Diane E. Brown and Victoria M. Virador and Takemi Tanaka and Fausto Andreola and Kathryn Strain and Barbara Dancheck and Rebeccah R Riley and Jeffrey Arbeit and Luigi M De Luca and Scott Kogan and Stuart H. Yuspa}, journal={Cancer research}, year={2003}, volume={63 17}, pages={5257-65} }