A PKC epsilon-ENH-channel complex specifically modulates N-type Ca2+ channels.

@article{MaenoHikichi2003APE,
  title={A PKC epsilon-ENH-channel complex specifically modulates N-type Ca2+ channels.},
  author={Yuka Maeno-Hikichi and Shaohua Chang and Kiyoyuki Matsumura and Meizan Lai and Hong Lin and Noritaka Nakagawa and Shun'ichi Kuroda and Ji-fang Zhang},
  journal={Nature neuroscience},
  year={2003},
  volume={6 5},
  pages={
          468-75
        }
}
Multiple protein kinase C (PKC) isozymes are present in neurons, where they regulate a variety of cellular functions. Due to the lack of specific PKC isozyme inhibitors, it remains unknown how PKC acts on its selective target(s) and achieves its specific actions. Here we show that a PKC binding protein, enigma homolog (ENH), interacts specifically with both PKCepsilon and N-type Ca2+ channels, forming a PKCepsilon-ENH-Ca2+ channel macromolecular complex. Coexpression of ENH facilitated… CONTINUE READING

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