A PIP2-derived amplification loop fuels the sustained initiation of B cell activation.

Abstract

Lymphocytes have evolved sophisticated signaling amplification mechanisms to efficiently activate downstream signaling after detection of rare ligands in their microenvironment. B cell receptor microscopic clusters (BCR microclusters) are assembled on the plasma membrane and recruit signaling molecules for the initiation of lymphocyte signaling after… (More)
DOI: 10.1126/sciimmunol.aan0787

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