A PHD finger motif in the C terminus of RAG2 modulates recombination activity.

@article{Elkin2005APF,
  title={A PHD finger motif in the C terminus of RAG2 modulates recombination activity.},
  author={Sheryl Krevsky Elkin and Dmitri N. Ivanov and Mark D Ewalt and Colin Ferguson and Sven G Hyberts and Zhen-yu J Sun and Glenn D. Prestwich and Junying Yuan and Gerhard Wagner and Marjorie A. Oettinger and Or P Gozani},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 31},
  pages={28701-10}
}
The RAG1 and RAG2 proteins catalyze V(D)J recombination and are essential for generation of the diverse repertoire of antigen receptor genes and effective immune responses. RAG2 is composed of a "core" domain that is required for the recombination reaction and a C-terminal nonessential or "non-core" region. Recent evidence has emerged arguing that the non-core region plays a critical regulatory role in the recombination reaction, and mutations in this region have been identified in patients… CONTINUE READING

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