A PEST-like sequence in the N-terminal cytoplasmic domain of Saccharomyces maltose permease is required for glucose-induced proteolysis and rapid inactivation of transport activity.

Abstract

Maltose permease is required for maltose transport into Saccharomyces cells. Glucose addition to maltose-fermenting cells causes selective delivery of this integral plasma membrane protein to the yeast vacuole via endocytosis for degradation by resident proteases. This glucose-induced degradation is independent of the proteasome but requires ubiquitin and… (More)

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@article{Medintz2000APS, title={A PEST-like sequence in the N-terminal cytoplasmic domain of Saccharomyces maltose permease is required for glucose-induced proteolysis and rapid inactivation of transport activity.}, author={Igor L. Medintz and X Wang and Tom{\'a}{\vs} Hr{\'a}dek and Corinna Michels}, journal={Biochemistry}, year={2000}, volume={39 15}, pages={4518-26} }