A PERIOD inhibitor buffer introduces a delay mechanism for CLK/CYC-activated transcription.

@article{Weber2003API,
  title={A PERIOD inhibitor buffer introduces a delay mechanism for CLK/CYC-activated transcription.},
  author={Frank Gerd Weber and Steve A Kay},
  journal={FEBS letters},
  year={2003},
  volume={555 2},
  pages={341-5}
}
We investigated the functions of clock genes period (per) and timeless (tim) in establishing negative feedback on circadian transcription factors clock/cycle (Clk/cyc) in Drosophila. We show that PER protein persists for several hours after rapid degradation of TIM in the morning. We observed in cell culture that isolated PER inhibits CLK/CYC-activated transcription in the absence of TIM and we further demonstrated for the first time in vivo that PER accumulation in a tim loss-of-function… CONTINUE READING

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