A PEGylated dendritic nanoparticulate carrier of fluorouracil.

  title={A PEGylated dendritic nanoparticulate carrier of fluorouracil.},
  author={Dipankar Bhadra and Sulekha Bhadra and Sanjay Jain and Narendra Kumar Jain},
  journal={International journal of pharmaceutics},
  volume={257 1-2},
The present study was aimed at developing and exploring the use of uncoated and PEGylated newer PAMAM dendrimers for delivery of anti-cancer drug 5-fluorouracil. For this study, successive Michael addition and exhaustive amidation reactions were used to synthesize 4.0 G PAMAM dendrimers, using ethylenediamine as core and methylmethacrylate as propagating agent. The dendrimer was PEGylated using N-hydroxysuccinimide-activated carboxymethyl MPEG-5000. IR and NMR data proved the synthesis. Various… CONTINUE READING


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