A PDZ-interacting domain in CFTR is an apical membrane polarization signal.

@article{Moyer1999APD,
  title={A PDZ-interacting domain in CFTR is an apical membrane polarization signal.},
  author={Bryan D Moyer and Jerod Scott Denton and Katherine H Karlson and Donna Reynolds and Sheng-lan Wang and James E. Mickle and Michał Milewski and Garry R. Cutting and Wm. B. Guggino and Minghua Li and Bruce A. Stanton},
  journal={The Journal of clinical investigation},
  year={1999},
  volume={104 10},
  pages={1353-61}
}
Polarization of the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-activated chloride channel, to the apical plasma membrane of epithelial cells is critical for vectorial transport of chloride in a variety of epithelia, including the airway, pancreas, intestine, and kidney. However, the motifs that localize CFTR to the apical membrane… CONTINUE READING