A PDZ domain protein interacts with the C-terminal tail of the insulin-like growth factor-1 receptor but not with the insulin receptor.

@article{Ligensa2001APD,
  title={A PDZ domain protein interacts with the C-terminal tail of the insulin-like growth factor-1 receptor but not with the insulin receptor.},
  author={Tanja Ligensa and Sybille Krau{\ss} and Daniel Demuth and Reto Schumacher and Jacques H. Camonis and Gabriele Jaques and Karla Marie Weidner},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 36},
  pages={
          33419-27
        }
}
In this study, we report on the isolation of a PDZ domain protein, here designated as IIP-1, insulin-like growth factor-1 (IGF-1) receptor-interacting protein-1, which binds to the IGF-1 receptor, but not to the related insulin receptor, and which is involved in the regulation of cell motility. The interaction between the IGF-1 receptor and IIP-1 as well as a splice variant IIP-1/p26 was demonstrated in the yeast two-hybrid system. Using co-precipitation experiments, we confirmed the… CONTINUE READING
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