A PDI family network acts distinctly and coordinately with ERp29 to facilitate polyomavirus infection.

@article{Walczak2011APF,
  title={A PDI family network acts distinctly and coordinately with ERp29 to facilitate polyomavirus infection.},
  author={Christopher Paul Walczak and Billy Tsai},
  journal={Journal of virology},
  year={2011},
  volume={85 5},
  pages={
          2386-96
        }
}
Endoplasmic reticulum (ER)-to-cytosol membrane transport is a decisive infection step for the murine polyomavirus (Py). We previously determined that ERp29, a protein disulfide isomerase (PDI) member, extrudes the Py VP1 C-terminal arm to initiate ER membrane penetration. This reaction requires disruption of Py's disulfide bonds. Here, we found that the PDI family members ERp57, PDI, and ERp72 facilitate virus infection. However, while all three proteins disrupt Py's disulfide bonds in vitro… CONTINUE READING
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