A PDGFRα-Mediated Switch toward CD9high Adipocyte Progenitors Controls Obesity-Induced Adipose Tissue Fibrosis.

@article{Marcelin2017APS,
  title={A PDGFRα-Mediated Switch toward CD9high Adipocyte Progenitors Controls Obesity-Induced Adipose Tissue Fibrosis.},
  author={Genevi{\`e}ve Marcelin and Adaliene Versiani de Matos Ferreira and Yuejun Liu and Michael Atlan and Judith Aron-Wisnewsky and V{\'e}ronique Pelloux and Yair Botbol and Marc Ambrosini and Magali Fradet and Christine Rouault and Corneliu H{\'e}n{\'e}gar and Jean-S{\'e}bastien Hulot and Christine Poitou and Adriana Torcivia and Raphael Nail-Barthelemy and Jean-Christophe Bichet and Emmanuel L. Gautier and Karine Cl{\'e}ment},
  journal={Cell metabolism},
  year={2017},
  volume={25 3},
  pages={673-685}
}
Obesity-induced white adipose tissue (WAT) fibrosis is believed to accelerate WAT dysfunction. However, the cellular origin of WAT fibrosis remains unclear. Here, we show that adipocyte platelet-derived growth factor receptor-α-positive (PDGFRα+) progenitors adopt a fibrogenic phenotype in obese mice prone to visceral WAT fibrosis. More specifically, a subset of PDGFRα+ cells with high CD9 expression (CD9high) originates pro-fibrotic cells whereas their CD9low counterparts, committed to… CONTINUE READING
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