A PDGF-Regulated Immediate Early Gene Response Initiates Neuronal Differentiation in Ventricular Zone Progenitor Cells

@article{Williams1997API,
  title={A PDGF-Regulated Immediate Early Gene Response Initiates Neuronal Differentiation in Ventricular Zone Progenitor Cells},
  author={Brenda P. Williams and John K. Park and John A. Alberta and Stephan G Muhlebach and Grace Y Hwang and Thomas M Roberts and Charles Dean Stiles},
  journal={Neuron},
  year={1997},
  volume={18},
  pages={553-562}
}
When exposed to platelet-derived growth factor (PDGF), uncommitted neuroepithelial cells from the developing cortex of embryonic day 14 (E14) rats develop into neurons. Outward signs of the neuronal phenotype are not observed for 4 days following exposure to PDGF. However, only a brief (2-3 hr) period of PDGF receptor activation is required to initiate neuronal development. During the window of receptor activation, RNA synthesis is essential, but protein synthesis is not. These observations… CONTINUE READING

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