A PDGF-Regulated Immediate Early Gene Response Initiates Neuronal Differentiation in Ventricular Zone Progenitor Cells

@article{Williams1997API,
  title={A PDGF-Regulated Immediate Early Gene Response Initiates Neuronal Differentiation in Ventricular Zone Progenitor Cells},
  author={B. Williams and J. K. Park and J. Alberta and S. Muhlebach and G. Y. Hwang and T. Roberts and C. Stiles},
  journal={Neuron},
  year={1997},
  volume={18},
  pages={553-562}
}
  • B. Williams, J. K. Park, +4 authors C. Stiles
  • Published 1997
  • Biology, Medicine
  • Neuron
  • When exposed to platelet-derived growth factor (PDGF), uncommitted neuroepithelial cells from the developing cortex of embryonic day 14 (E14) rats develop into neurons. Outward signs of the neuronal phenotype are not observed for 4 days following exposure to PDGF. However, only a brief (2-3 hr) period of PDGF receptor activation is required to initiate neuronal development. During the window of receptor activation, RNA synthesis is essential, but protein synthesis is not. These observations… CONTINUE READING

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