A PD-1 polymorphism is associated with disease progression in multiple sclerosis.

@article{Kroner2005APP,
  title={A PD-1 polymorphism is associated with disease progression in multiple sclerosis.},
  author={Antje Kroner and Matthias Mehling and Bernhard Hemmer and Peter Rieckmann and Klaus Viktor Toyka and Mathias Maeurer and Heinz Wiendl},
  journal={Annals of neurology},
  year={2005},
  volume={58 1},
  pages={50-7}
}
T cells are considered to play a pivotal role in orchestrating the self-reactive immune responses in multiple sclerosis (MS). Programmed death 1 (PD-1) is a member of the B7/CD28 superfamily of costimulatory molecules exerting inhibitory functions on T cells. Recently, an intronic 7146G/A polymorphism within the PD-1 gene was described and suggested to be associated with autoimmunity. We investigated whether this genetic polymorphism is a genetic modifier for risk and progression of MS. Blood… CONTINUE READING