A PAMPA Study of the Permeability‐Enhancing Effect of New Ceramide Analogues

@article{Sink2009APS,
  title={A PAMPA Study of the Permeability‐Enhancing Effect of New Ceramide Analogues},
  author={B. Sink{\'o} and J. K{\"o}k{\"o}si and A. Avdeef and K. Tak{\'a}cs‐Nov{\'a}k},
  journal={Chemistry \& Biodiversity},
  year={2009},
  volume={6}
}
There is a major need in drug discovery for quick, precise, and cost‐effective high‐throughput screening (HTS) systems in the early stages of drug research. The Parallel Artificial Membrane Permeability Assay (PAMPA) aims at predicting the passive membrane properties of drugs. Since 1998, model membranes have been developed to predict gastro‐intestinal absorption or transport through the blood–brain barrier. This paper presents recent results in a project aiming to improve the prediction of… Expand
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35 Citations
Background Citations
16
Methods Citations
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35 Citations

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Citation Type

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Ceramides are essential components in the stratum corneum barrier function. Different classes of ceramides are present in human skin, differing in the nature of sphingosine and acyl moieties with… Expand
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The Influence of the Acyl Chain on the Transdermal Penetration-Enhancing Effect of Synthetic Phytoceramides
TLDR
The investigated PCERs exhibited a penetration-enhancing effect on caffeine and testosterone but not on ibuprofen, which may facilitate the passage of drugs through the stratum corneum. Expand
PAMPA study of the temperature effect on permeability.
TLDR
The Skin PamPA(™) proved to be the most sensitive on temperature alteration, though GIT and BBB PAMPA results were also affected, and the importance of human-relevant incubation conditions at in vitro assays is concluded for the better in vivo prediction. Expand
Interactions between fluoroquinolones and lipids : biophysical studies
Probing fluoroquinolones/lipid interactions at the molecular level represents an important challenge in both membrane biophysics and pharmaceutical research. As the pharmacological target of these… Expand
Drug permeability pro fi ling using cell-free permeation tools : Overview and applications
Cell-free permeation systems are gaining interest in drug discovery and development as tools to obtain a reliable prediction of passive intestinal absorption without the disadvantages associated with… Expand
Optimization of experimental conditions for skin-PAMPA measurements
In recent years, the parallel artificial membrane permeability assay (PAMPA) has been extended for prediction of skin permeation by developing an artificial membrane which mimics the stratum corneum… Expand
Skin-PAMPA: a new method for fast prediction of skin penetration.
TLDR
It was shown that skin-PAMPA is a quick and cost-effective research tool that can serve as a useful model of skin penetration in pharmaceutical and cosmetic research. Expand
Assessing vehicle effects on skin absorption using artificial membrane assays.
  • D. Karadzovska, J. Riviere
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2013
TLDR
Three artificial membranes were evaluated for their ability to predict the skin permeability of caffeine, cortisone, diclofenac sodium, mannitol, salicylic acid and testosterone applied in propylene glycol, water and ethanol as unsaturated and saturated concentrations and identified different physicochemical factors influencing the absorption process. Expand
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