A PAI-1 ( SERPINE 1 ) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia : a report from the Children ’ s Oncology Group

@inproceedings{French2008AP,
  title={A PAI-1 ( SERPINE 1 ) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia : a report from the Children ’ s Oncology Group},
  author={Deborah French and Leo H. Hamilton and Leonard A. Mattano and Harland N. Sather and Meenakshi Devidas and James B. Nachman and Mary V. Relling},
  year={2008}
}
As glucocorticoid use increased in acute lymphoblastic leukemia, osteonecrosis became an increasingly frequent complication. Besides increased age, host risk factors are poorly defined. We tested whether 12 polymorphisms were associated with osteonecrosis among patients 10 years and older treated on the CCG1882 protocol. Candidate genes (TYMS, MTHFR, ABCB1, BGLAP, ACP5, LRP5, ESR1, PAI-1, VDR, PTH, and PTHR) were chosen based on putative mechanisms underlying osteonecrosis risk. All children… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Pharmacogenetic risk factors for osteonecrosis of the hip among children with leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2004

Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2003

Similar Papers

Loading similar papers…