A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking.

@article{Scott2006APG,
  title={A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking.},
  author={Gregory K. Scott and Hao Fei and Laurel Thomas and Guruprasad R Medigeshi and Gary Thomas},
  journal={The EMBO journal},
  year={2006},
  volume={25 19},
  pages={4423-35}
}
The cation-independent mannose-6-phosphate receptor (CI-MPR) follows a highly regulated sorting itinerary to deliver hydrolases from the trans-Golgi network (TGN) to lysosomes. Cycling of CI-MPR between the TGN and early endosomes is mediated by GGA3, which directs TGN export, and PACS-1, which directs endosome-to-TGN retrieval. Despite executing opposing sorting steps, GGA3 and PACS-1 bind to an overlapping CI-MPR trafficking motif and their sorting activity is controlled by the CK2… CONTINUE READING

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