A One-Pot, fast, and efficient amidation of carboxylic acids, α-amino acids and sulfonic acids using pph3/n-chlorobenzotriazole system

  title={A One-Pot, fast, and efficient amidation of carboxylic acids, $\alpha$-amino acids and sulfonic acids using pph3/n-chlorobenzotriazole system},
  author={Hamed Rouhi-Saadabad and Batool Akhlaghinia},
  journal={Phosphorus, Sulfur, and Silicon and the Related Elements},
  pages={1703 - 1714}
GRAPHICAL ABSTRACT Abstract Triphenylphosphine (PPh3)/N-chlorobenzotriazole (NCBT), and amine (primary and secondary aliphatic amines and also substituted anilines) in CH2Cl2 efficiently converted carboxylic acids, α-amino acids, and sulfonic acids to the corresponding amides and sulfonamides at room temperature. Good to excellent yields, inexpensive, and fast reaction conditions are the important features of this procedure. 
3 Citations
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