A Nucleosomal Region Important for Ensuring Proper Interactions Between the Transcription Elongation Factor Spt16 and Transcribed Genes in Saccharomyces cerevisiae

@inproceedings{Nguyen2013ANR,
  title={A Nucleosomal Region Important for Ensuring Proper Interactions Between the Transcription Elongation Factor Spt16 and Transcribed Genes in Saccharomyces cerevisiae},
  author={Hoai-Trang T. Nguyen and William Wharton and Jennifer A. Harper and James R. Dornhoffer and Andrea A Duina},
  booktitle={G3},
  year={2013}
}
The highly conserved FACT (FAcilitates Chromatin Transactions) histone chaperone assists in the transcription elongation process first by facilitating the removal of histones in front of transcribing RNA polymerase II (Pol II) and then by contributing to nucleosome reassembly in the wake of Pol II passage. Whereas it is well established that FACT localizes across actively transcribed genes, the mechanisms that regulate FACT recruitment to and disengagement from chromatin during transcription… CONTINUE READING

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