A Nuclear Receptor Ligand Down-Regulates Cytosolic Phospholipase A 2 Expression to Reduce Bile Acid–Induced Cyclooxygenase 2 Activity in Cholangiocytes: Implications of Anticarcinogenic Action of Farnesoid X Receptor Agonists

@article{Komichi2005ANR,
  title={A Nuclear Receptor Ligand Down-Regulates Cytosolic Phospholipase A 2 Expression to Reduce Bile Acid–Induced Cyclooxygenase 2 Activity in Cholangiocytes: Implications of Anticarcinogenic Action of Farnesoid X Receptor Agonists},
  author={Daisuke Komichi and PhD Susumu Tazuma and Phd Tomoji Nishioka and Phd Hideyuki Hyogo and Phd Kazuaki Chayama},
  journal={Digestive Diseases and Sciences},
  year={2005},
  volume={50},
  pages={514-524}
}
Bile acids are considered to be involved in the development of biliary tract carcinoma, although the underlying mechanisms are yet to be established. The aims of this study were (1) to investigate the carcinogenic role of bile acids in the biliary system based on the arachidonate–prostanoid pathway and (2) to clarify the therapeutic role of a farnesoid X receptor (FXR) ligand that modifies bile acid metabolism. Immortalized mouse cholangiocytes were incubated with glycochenodeoxycholate (GCDC… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Differential expression of cyclooxygenase522 Digestive Diseases and Sciences, Vol

N Hayashi, H Yamamoto, +10 authors M Monden
50, No. 3 • 2005
View 4 Excerpts
Highly Influenced

Taurocholate feeding prevents CCl4-induced damage Digestive Diseases and Sciences, Vol

L Marucci, G Alpini, +10 authors G LeSage
50, No. 3 • 2005

Similar Papers

Loading similar papers…