A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

@article{Sutendra2014ANP,
  title={A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation},
  author={Gopinath Sutendra and Adam S Kinnaird and Peter Dromparis and Roxane Paulin and Trevor H. Stenson and Alois Haromy and Kyoko Hashimoto and Nancy Y Zhang and Eric Flaim and Evangelos D Michelakis},
  journal={Cell},
  year={2014},
  volume={158},
  pages={84-97}
}
DNA transcription, replication, and repair are regulated by histone acetylation, a process that requires the generation of acetyl-coenzyme A (CoA). Here, we show that all the subunits of the mitochondrial pyruvate dehydrogenase complex (PDC) are also present and functional in the nucleus of mammalian cells. We found that knockdown of nuclear PDC in isolated functional nuclei decreased the de novo synthesis of acetyl-CoA and acetylation of core histones. Nuclear PDC levels increased in a cell… CONTINUE READING
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