A Novel and Highly Divergent Homolog of Human Eosinophil Granule Major Basic Protein*

  title={A Novel and Highly Divergent Homolog of Human Eosinophil Granule Major Basic Protein*},
  author={Douglas A. Plager and David A. Loegering and Deborah A. Weiler and James L. Checkel and Jill M. Wagner and Nigel J. Clarke and Stephen Naylor and Scott M. Page and Larry L. Thomas and Ingrid E. Akerblom and Ben Cocks and Susan G. Stuart and Gerald J. Gleich},
  journal={The Journal of Biological Chemistry},
  pages={14464 - 14473}
Eosinophils are important effector cells in defense against helminth infection and in allergic diseases. To identify novel eosinophil proteins, large scale sequencing of a cDNA library prepared from interleukin-5-stimulated umbilical cord precursor cells was performed, and the major genes expressed by maturing eosinophils were determined. This resulted in the identification of a cDNA with 64% identity to human prepro-major basic protein (hprepro-MBP). This cDNA was designated hprepro-MBP… 

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