A Novel ZAP-70 Dependent FRET Based Biosensor Reveals Kinase Activity at both the Immunological Synapse and the Antisynapse

@article{Randriamampita2008ANZ,
  title={A Novel ZAP-70 Dependent FRET Based Biosensor Reveals Kinase Activity at both the Immunological Synapse and the Antisynapse},
  author={Clotilde Randriamampita and Pierre Mouchacca and Bernard Malissen and Didier Marguet and Alain Trautmann and Annemarie Coffman Lellouch},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={69 - 80}
}
Many hypotheses attempting to explain the speed and sensitivity with which a T-cell discriminates the antigens it encounters include a notion of relative spatial and temporal control of particular biochemical steps involved in the process. An essential step in T-cell receptor (TCR) mediated signalling is the activation of the protein tyrosine kinase ZAP-70. ZAP-70 is recruited to the TCR upon receptor engagement and, once activated, is responsible for the phosphorylation of the protein adaptor… CONTINUE READING
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