A Novel Tropically Stable Oral Amphotericin B Formulation (iCo-010) Exhibits Efficacy against Visceral Leishmaniasis in a Murine Model

@inproceedings{Wasan2010ANT,
  title={A Novel Tropically Stable Oral Amphotericin B Formulation (iCo-010) Exhibits Efficacy against Visceral Leishmaniasis in a Murine Model},
  author={Ellen K. Wasan and Pavel Gershkovich and Jinying Zhao and Xiaohua Zhu and Karl A. Werbovetz and Richard R. Tidwell and John G. Clement and Sheila J. Thornton and Kishor M. Wasan},
  booktitle={PLoS neglected tropical diseases},
  year={2010}
}
PURPOSE To develop an oral formulation of amphotericin B (AmB) that is stable at the temperatures of WHO Climatic Zones 3 and 4 (30-43 °C) and to evaluate its efficacy in a murine model of visceral leishmaniasis (VL). METHODS The stability testing of four novel oral lipid AmB formulations composed of mono- and di-glycerides and pegylated esters (iCo-010 to iCo-013) was performed over 60 d and analyzed by HPLC-UV. In addition, the four formulations were incubated 4 h in fasted-state simulated… CONTINUE READING

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