A Novel Swine Model of Spontaneous Hypertension With Sympathetic Hyperactivity Responds Well to Renal Denervation.

@article{Li2016ANS,
  title={A Novel Swine Model of Spontaneous Hypertension With Sympathetic Hyperactivity Responds Well to Renal Denervation.},
  author={Dan Li and Qiang Sheng Wang and Yan Zhang and De Zhi Li and Dachun Yang and Shujie Wei and Linan Su and Tingqiao Ye and Xi Zheng and Ke Peng and Liping Zhang and Yunrong Zhang and Yongjian Yang and Shuangtao Ma},
  journal={American journal of hypertension},
  year={2016},
  volume={29 1},
  pages={63-72}
}
BACKGROUND The large animal model of arterial hypertension is very valuable to test the antihypertensive drugs and devices. We characterized a novel swine model of spontaneous hypertension and investigated its response to renal denervation (RDN). METHODS The blood pressure (BP), levels of plasma catecholamines and urine vanillylmandelic acid, and the protein expressions of angiotensin-converting enzyme (ACE) and angiotensin II type 1 (AT1), and type 2 (AT2) receptors in the rostral… CONTINUE READING