A Novel Strategy for Surface Modification of Superparamagnetic Iron Oxide Nanoparticles for Lung Cancer Imaging.

@article{Huang2009ANS,
  title={A Novel Strategy for Surface Modification of Superparamagnetic Iron Oxide Nanoparticles for Lung Cancer Imaging.},
  author={Gang Huang and Chunfu Zhang and Shunzi Li and Chalermchai Khemtong and Su-Geun Yang and Ruhai Tian and John D. Minna and Kathlynn C. Brown and Jinming Gao},
  journal={Journal of materials chemistry},
  year={2009},
  volume={19},
  pages={6367-6372}
}
Superparamagnetic iron oxide (SPIO) nanoparticles are widely used in magnetic resonance imaging (MRI) as versatile ultra-sensitive nanoprobes for cellular and molecular imaging of cancer. In this study, we report a one-step procedure for the surface functionalization of SPIO nanoparticles with a lung cancer-targeting peptide. The hydrophobic surfactants on the as-synthesized SPIO are displaced by the peptide containing a poly(ethylene glycol)-tethered cysteine residue through ligand exchange… CONTINUE READING
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