Angiotensin-converting enzyme (ACE) (EC 4.15.1) metabolizes many biologically active peptides and plays a key role in blood pressure regulation and vascular remodeling. Elevated ACE levels are associated with different cardiovascular and respiratory diseases.
METHODS AND RESULTS
Two Belgian families with a 8-16-fold increase in blood ACE level… (More)
Figure 1. Genealogic tree of the two families harboring the IVS25+1G.A mutation. Genealogic tree of the two Belgian families harboring the IVS25+1G.A mutation, showing the circulating ACE levels and the genotypes at the IVS25+1 and I/D loci. Circulating ACE was determined with