A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells.

@article{Alhazzazi2016ANS,
  title={A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells.},
  author={Turki Y. Alhazzazi and Pachiyappan Kamarajan and Yanli Xu and Teng Ai and Liqiang Chen and Eric Verdin and Yvonne L Kapila},
  journal={Anticancer research},
  year={2016},
  volume={36 1},
  pages={49-60}
}
BACKGROUND The survival rate of patients with head and neck squamous cell carcinoma (HNSCC) stands at approximately 50% and this has not improved in decades. This study developed a novel sirtuin-3 (SIRT3) inhibitor (LC-0296) and examined its role in altering HNSCC tumorigenesis. MATERIALS AND METHODS The effect of the SIRT3 inhibitor, LC-0296, on cell… CONTINUE READING