A Novel Signaling Network Essential for Regulating Pseudomonas aeruginosa Biofilm Development

@inproceedings{Petrova2009ANS,
  title={A Novel Signaling Network Essential for Regulating Pseudomonas aeruginosa Biofilm Development},
  author={Olga E. Petrova and Karin Sauer},
  booktitle={PLoS pathogens},
  year={2009}
}
The important human pathogen Pseudomonas aeruginosa has been linked to numerous biofilm-related chronic infections. Here, we demonstrate that biofilm formation following the transition to the surface attached lifestyle is regulated by three previously undescribed two-component systems: BfiSR (PA4196-4197) harboring an RpoD-like domain, an OmpR-like BfmSR (PA4101-4102), and MifSR (PA5511-5512) belonging to the family of NtrC-like transcriptional regulators. These two-component systems become… CONTINUE READING

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