A Novel SDHA-deficient Renal Cell Carcinoma Revealed by Comprehensive Genomic Profiling.

@article{Yakirevich2015ANS,
  title={A Novel SDHA-deficient Renal Cell Carcinoma Revealed by Comprehensive Genomic Profiling.},
  author={Evgeny Yakirevich and Siraj M Ali and Anthony Mega and Caitlin R McMahon and Alexander Brodsky and Jeffrey S. Ross and Justin R Allen and Julia A Elvin and Howard P. Safran and Murray B. Resnick},
  journal={The American journal of surgical pathology},
  year={2015},
  volume={39 6},
  pages={858-63}
}
Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (RCC) is an emerging provisional entity included in the 2013 International Society of Urological Pathology Vancouver Classification. Most genomic alterations in patients with SDH-deficient RCCs involve the SDHB subunit, and the associated renal tumors have loss of immunohistochemical SDHB expression and distinctive morphologic features. Renal tumors less commonly possess genomic alterations involving the SDHC and SDHD subunits, but no… CONTINUE READING

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