A Novel Role of the Budding Yeast Separin Esp1 in Anaphase Spindle Elongation

  title={A Novel Role of the Budding Yeast Separin Esp1 in Anaphase Spindle Elongation},
  author={Sanne Jensen and Marisa Segal and Duncan J Clarke and S. I. Reed},
  journal={The Journal of Cell Biology},
  pages={27 - 40}
In Saccharomyces cerevisiae, the metaphase-anaphase transition is initiated by the anaphase-promoting complex-dependent degradation of Pds1, whereby Esp1 is activated to promote sister chromatid separation. Although this is a fundamental step in the cell cycle, little is known about the regulation of Esp1 and how loss of cohesion is coordinated with movement of the anaphase spindle. Here, we show that Esp1 has a novel role in promoting anaphase spindle elongation. The localization of Esp1 to… CONTINUE READING


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