A Novel Role of Protein Tyrosine Kinase2 in Mediating Chloride Secretion in Human Airway Epithelial Cells

@inproceedings{Liang2011ANR,
  title={A Novel Role of Protein Tyrosine Kinase2 in Mediating Chloride Secretion in Human Airway Epithelial Cells},
  author={Lihua Liang and Owen M Woodward and Zhaohui Chen and Robert Cotter and William B Guggino},
  booktitle={PloS one},
  year={2011}
}
Ca(2+) activated Cl(-) channels (CaCC) are up-regulated in cystic fibrosis (CF) airway surface epithelia. The presence and functional properties of CaCC make it a possible therapeutic target to compensate for the deficiency of Cl(-) secretion in CF epithelia. CaCC is activated by an increase in cytosolic Ca(2+), which not only activates epithelial CaCCs… CONTINUE READING