A Novel Rodent Model That Mimics the Metabolic Sequelae of Obese Craniopharyngioma Patients

@article{Roth2011ANR,
  title={A Novel Rodent Model That Mimics the Metabolic Sequelae of Obese Craniopharyngioma Patients},
  author={Christian L Roth and James E. Blevins and Melissa Ralston and Clinton Thomas Elfers and Kayoko Ogimoto and Karl J Kaiyala and Gregory J. Morton},
  journal={Pediatric Research},
  year={2011},
  volume={69},
  pages={230-236}
}
Patients with craniopharyngioma (CP), a tumor located in the pituitary and/or hypothalamus, are susceptible to developing obesity and many metabolic complications. The study aim was to create a rodent model that mimics the complex neuroanatomical and metabolic disturbances commonly seen in obese CP patients. We compared the metabolic phenotype of animals with three distinct types of hypothalamic lesions: 1) destruction of the arcuate nucleus (ARC) induced by monosodium glutamate (MSG), 2… CONTINUE READING