A Novel Retinoblastoma Therapy from Genomic and Epigenetic Analyses

@inproceedings{Zhang2012ANR,
  title={A Novel Retinoblastoma Therapy from Genomic and Epigenetic Analyses},
  author={Jinghui Zhang and Claudia A. Benavente and Justina D. McEvoy and Jacqueline Flores-Otero and Li Ding and Xiang Chen and Anatoly Ulyanov and Gang Wu and Matthew W. Wilson and Jianmin Wang and Rachel C. Brennan and Michael C Rusch and Amity L. Manning and Lei Qiao and John Easton and Sheila Shurtleff and Charles G Mullighan and Stanley B Pounds and Suraj T Mukatira and Pankaj Gupta and Geoff Neale and David Zhao and Charles Lu and Robert F Sir Fulton and Lucinda L. Fulton and Xin Hong and D. James Dooling and Kerri Ochoa and Clayton W. Naeve and Nicholas John Dyson and Elaine R. Mardis and Armita Bahrami and D W Ellison and Richard K. Wilson and James R. Downing and Michael A. Dyer},
  booktitle={Nature},
  year={2012}
}
Retinoblastoma is an aggressive childhood cancer of the developing retina that is initiated by the biallelic loss of RB1. Tumours progress very quickly following RB1 inactivation but the underlying mechanism is not known. Here we show that the retinoblastoma genome is stable, but that multiple cancer pathways can be epigenetically deregulated. To identify the mutations that cooperate with RB1 loss, we performed whole-genome sequencing of retinoblastomas. The overall mutational rate was very low… CONTINUE READING
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