A Novel Protein-Protein Interaction in the RES (REtention and Splicing) Complex*

  title={A Novel Protein-Protein Interaction in the RES (REtention and Splicing) Complex*},
  author={K Tripsianes and Anders R Friberg and Charlotte Barrandon and Mark Adrian Brooks and Herman Van Tilbeurgh and Bertrand S{\'e}raphin and Michael Sattler},
  booktitle={The Journal of biological chemistry},
The retention and splicing (RES) complex is a conserved spliceosome-associated module that was shown to enhance splicing of a subset of transcripts and promote the nuclear retention of unspliced pre-mRNAs in yeast. The heterotrimeric RES complex is organized around the Snu17p protein that binds to both the Bud13p and Pml1p subunits. Snu17p exhibits an RRM domain that resembles a U2AF homology motif (UHM) and Bud13p harbors a Trp residue reminiscent of an UHM-ligand motif (ULM). It has therefore… CONTINUE READING
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