A Novel Polymorphism of the CYP4A11 Gene is Associated With Coronary Artery Disease

@article{Fu2013ANP,
  title={A Novel Polymorphism of the CYP4A11 Gene is Associated With Coronary Artery Disease},
  author={Zhen-Yan Fu and Yi-Tong Ma and Xiang Xie and Ding Huang and Hong Yang and Tomohiro Nakayama and Naoyuki Sato},
  journal={Clinical and Applied Thrombosis/Hemostasis},
  year={2013},
  volume={19},
  pages={60 - 65}
}
Background: CYP4A11 (cytochrome P450, family 4, subfamily A, polypeptide 11) converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which plays a crucial role in the modulation of cardiovascular homeostasis. The aim of the present study was to assess the association between the human CYP4A11 gene and coronary artery disease (CAD). Methods: A total of 361 patients with CAD and 315 controls were genotyped for 4 single-nucleotide polymorphisms (SNPs) of the human CYP4A11 gene… Expand
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