A Novel Physiologically-Based Mechanistic Model for Predicting Oral Drug Absorption: The Advanced Dissolution, Absorption, and Metabolism (ADAM) Model.

@inproceedings{Jamei2007ANP,
  title={A Novel Physiologically-Based Mechanistic Model for Predicting Oral Drug Absorption: The Advanced Dissolution, Absorption, and Metabolism (ADAM) Model.},
  author={Mohammad Masjed Jamei and Jian-hu Yang and Dann Turner and Karen Rowland-Yeo and Geoffrey T. Tucker and Amin Rostami-Hochaghan},
  year={2007}
}
1 2 3 4 5 6 7 8 9 10 The Advanced Dissolution, Absorption and Metabolism (ADAM) model, as implemented in Simcyp© Version 7, predicts the rates and extents of intestinal drug absorption and metabolism and their associated inter-individual variability. The model is a population-based mechanistic representation which accounts for the heterogeneity of the gastrointestinal tract and considers the processes of dissolution, regio-specifi c gastrointestinal fluid dynamics, gut wall permeability and gut… CONTINUE READING