A Novel Naphthalimide Compound Restores p53 Function in Non-small Cell Lung Cancer by Reorganizing the Bak·Bcl-xl Complex and Triggering Transcriptional Regulation.

@article{Zhang2016ANN,
  title={A Novel Naphthalimide Compound Restores p53 Function in Non-small Cell Lung Cancer by Reorganizing the Bak·Bcl-xl Complex and Triggering Transcriptional Regulation.},
  author={Guohai Zhang and Yunfeng An and Xing Lu and Hui Zhong and Yanhong Zhu and Yiming Wu and Feng'e Ma and Jingmei Yang and Yancheng Liu and Zuping Zhou and Yan Peng and Zhen-Feng Chen},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 8},
  pages={4211-25}
}
p53 inactivation is a hallmark in non-small-cell lung cancer (NSCLC). It is therefore highly desirable to develop tumor-specific treatment for NSCLC therapy by restoring p53 function. Herein, a novel naphthalimide compound, NA-17, was identified as a promising drug candidate in view of both its anticancer activity and mechanism of action. NA-17 exhibited strong anticancer activity on a broad range of cancer cell lines but showed low toxicity to normal cell lines, such as HL-7702 and WI-38… CONTINUE READING
5 Citations
39 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 39 references

hp://w w w .jb.org/ D ow nladed from Novel naphthalimide restores p53 function

  • E. Van-Quaquebeke, T. Mahieu, +12 authors R. Kiss
  • U iv of W etern A uralia on D ecem er 17,
  • 2015
1 Excerpt

Similar Papers

Loading similar papers…