A Novel NHE1-Centered Signaling Cassette Drives Epidermal Growth Factor Receptor–Dependent Pancreatic Tumor Metastasis and Is a Target for Combination Therapy1

@inproceedings{Cardone2015ANN,
  title={A Novel NHE1-Centered Signaling Cassette Drives Epidermal Growth Factor Receptor–Dependent Pancreatic Tumor Metastasis and Is a Target for Combination Therapy1},
  author={Rosa Angela Cardone and Maria Raffaella Greco and Katrine Zeeberg and A Zaccagnino and Mara Saccomano and Antonia Bellizzi and Philipp Bruns and Marta Menga and Christian Pilarsky and Albrecht Schwab and Frauke Alves and Holger Kalthoff and Valeria Casavola and Stephan Joel Reshkin},
  booktitle={Neoplasia},
  year={2015}
}
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers principally because of early invasion and metastasis. The epidermal growth factor receptor (EGFR) is essential for PDAC development even in the presence of Kras, but its inhibition with erlotinib gives only a modest clinical response, making the discovery of novel EGFR targets of critical interest. Here, we revealed by mining a human pancreatic gene expression database that the metastasis promoter Na(+)/H(+) exchanger… CONTINUE READING
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