A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration

  title={A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration},
  author={G{\'a}bor Erős and Petra Hartmann and Szilvia Berk{\'o} and Eszter Csizmazia and Erzs{\'e}bet Cs{\'a}nyi and Anita Sztojkov-Ivanov and Istv{\'a}n Bal{\'a}zs N{\'e}meth and P Szab{\'o}-R{\'e}v{\'e}sz and Istv{\'a}n Zupk{\'o} and Lajos Kem{\'e}ny},
Enhancement of the transdermal penetration of different active agents is an important research goal. Our aim was to establish a novel in vivo experimental model which provides a possibility for exact measurement of the quantity of penetrated drug. The experiments were performed on SKH-1 hairless mice. A skin fold in the dorsal region was fixed with two fenestrated titanium plates. A circular wound was made on one side of the skin fold. A metal cylinder with phosphate buffer was fixed into the… CONTINUE READING

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Penetration enhancer e ff ect of sucrose laurate and Transcutol on ibuprofen

  • G. Erős E. Csizmazia, O. Berkesi, S. Berkó, P. Szabó-Révész, E. Csányi
  • Journal of Drug Delivery Science and Technology
  • 2011

and E

  • E. Csizmazia, G. Erős, O. Berkesi, S. Berkó, P. Szabó-Révész
  • Csányi, “Penetration enhancer effect of sucrose…
  • 2011

and K

  • K. Yan, H. Todo
  • Sugibayashi, “Transdermal drug delivery by in…
  • 2010
1 Excerpt


  • M. W. Laschke, A. Strohe
  • Scheuer et al., “In vivo biocompatibility and…
  • 2009
1 Excerpt

and R

  • S. Heuschkel, J. Wohlrab
  • H. H. Neubert, “Dermal and transdermal targeting…
  • 2009
1 Excerpt

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