A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration

@inproceedings{Ers2012ANM,
  title={A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration},
  author={G{\'a}bor Erős and Petra Hartmann and Szilvia Berk{\'o} and Eszter Csizmazia and Erzs{\'e}bet Cs{\'a}nyi and Anita Sztojkov-Ivanov and Istv{\'a}n Bal{\'a}zs N{\'e}meth and P Szab{\'o}-R{\'e}v{\'e}sz and Istv{\'a}n Zupk{\'o} and Lajos Kem{\'e}ny},
  booktitle={TheScientificWorldJournal},
  year={2012}
}
Enhancement of the transdermal penetration of different active agents is an important research goal. Our aim was to establish a novel in vivo experimental model which provides a possibility for exact measurement of the quantity of penetrated drug. The experiments were performed on SKH-1 hairless mice. A skin fold in the dorsal region was fixed with two fenestrated titanium plates. A circular wound was made on one side of the skin fold. A metal cylinder with phosphate buffer was fixed into the… CONTINUE READING

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