A Novel Multi-Antigen Virally Vectored Vaccine against Mycobacterium avium Subspecies paratuberculosis

@article{Bull2007ANM,
  title={A Novel Multi-Antigen Virally Vectored Vaccine against Mycobacterium avium Subspecies paratuberculosis},
  author={Tim John Bull and Sarah C Gilbert and Saranya Sridhar and Richard Linedale and Nicola Dierkes and Karim Sidi-Boumedine and John Hermon-Taylor},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={329 - 363}
}
BACKGROUND Mycobacterium avium subspecies paratuberculosis causes systemic infection and chronic intestinal inflammation in many species including primates. Humans are exposed through milk and from sources of environmental contamination. Hitherto, the only vaccines available against Mycobacterium avium subspecies paratuberculosis have been limited to veterinary use and comprised attenuated or killed organisms. METHODS We developed a vaccine comprising a fusion construct designated HAV… CONTINUE READING

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