A Novel Molecule (Frakefamide) with Peripheral Opioid Properties: The Effects on Resting Ventilation Compared with Morphine and Placebo

@article{Modalen2005ANM,
  title={A Novel Molecule (Frakefamide) with Peripheral Opioid Properties: The Effects on Resting Ventilation Compared with Morphine and Placebo},
  author={Asa Osterlund Modalen and Hans Quiding and Joana Frey and Lars Westman and Sten G. E. Lindahl},
  journal={Anesthesia \& Analgesia},
  year={2005},
  volume={100},
  pages={713-717}
}
In animal models frakefamide (FF) is a potent analgesic that acts as a peripheral active &mgr;-selective receptor agonist. In this double-blind, randomized, double dummy four-way crossover study in 12 healthy male subjects, we investigated the effects on resting ventilation of FF and 2 dose levels of morphine compared with placebo. Each drug was infused for 6 h. The subjects received 1.22 mg/kg FF, 0.43 mg/kg morphine (M-large), and 0.11 mg/kg morphine (M-small). Sodium chloride 9 mg/mL was… 

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