A Novel Method of 18 F Radiolabeling for PET

  title={A Novel Method of 18 F Radiolabeling for PET},
  author={William J H Mcbride and Robert M Sharkey and Habibe Karacay and Christopher A. D’Souza and Edmund A. Rossi and Peter Laverman and Chien-Hsing Chang and Otto C Boerman and David M. Goldenberg},
Small biomolecules are typically radiolabeled with 18F by binding it to a carbon atom, a process that usually is designed uniquely for each new molecule and requires several steps and hours to produce. We report a facile method wherein 18F is first attached to aluminum as Al18F, which is then bound to a chelate attached to a peptide, forming a stable Al18F-chelate-peptide complex in an efficient 1-pot process. Methods: For proof of principle, this method was applied to a peptide suitable for… CONTINUE READING


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