A Novel Mechanism of Programmed Cell Death in Bacteria by Toxin–Antitoxin Systems Corrupts Peptidoglycan Synthesis

Abstract

Most genomes of bacteria contain toxin-antitoxin (TA) systems. These gene systems encode a toxic protein and its cognate antitoxin. Upon antitoxin degradation, the toxin induces cell stasis or death. TA systems have been linked with numerous functions, including growth modulation, genome maintenance, and stress response. Members of the epsilon/zeta TA… (More)
DOI: 10.1371/journal.pbio.1001033

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@inproceedings{Mutschler2011ANM, title={A Novel Mechanism of Programmed Cell Death in Bacteria by Toxin–Antitoxin Systems Corrupts Peptidoglycan Synthesis}, author={H C Ernst Mutschler and Maike Gebhardt and Robert L. Shoeman and Anton Meinhart}, booktitle={PLoS biology}, year={2011} }