A Novel Mechanism for Nicotinic Potentiation of Glutamatergic Synapses

  title={A Novel Mechanism for Nicotinic Potentiation of Glutamatergic Synapses},
  author={Andrew W Halff and David G{\'o}mez-Varela and Danielle John and Darwin K. Berg},
  journal={The Journal of Neuroscience},
  pages={2051 - 2064}
Selective strengthening of specific glutamatergic synapses in the mammalian hippocampus is critical for encoding new memories. This is most commonly achieved by input-specific Hebbian-type plasticity involving glutamate-dependent coincident presynaptic and postsynaptic depolarization. Our results demonstrate a novel mechanism by which nicotinic signaling, independently of coincident fast glutamatergic transmission, increases synaptic strength in the hippocampus. Electrophysiological recordings… 

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